The second “Hot Topic Day” of the APGI will be dedicated to a particularly challenging aim in pharmaceutical formulation:
Site-specific drug delivery
to the colon
The idea is to minimize drug release in the upper part of the gastro intestinal tract (stomach and small intestine), and to delivery the drug specifically to the colon. This type of systems can be very helpful to improve the efficacy of local drug treatments of the colon, such as chronic inflammatory bowel diseases (e.g. Crohn’s disease and ulcerative colitis). Also, the way could be paved for a holy grail in our field: The oral delivery of biopharmaceuticals for systemic action.
A variety of strategies has been proposed to allow for colon targeting, including dosage forms with polymeric coatings exhibiting pH dependent solubility, systems which are preferentially degraded by enzymes secreted by bacteria present in the colon, and/or “time-controlled” devices, which release the drug after a pre-programmed lag-time (e.g., due to the rupturing of an outer film coating). A large spectrum of excipients and manufacturing techniques has been suggested with more or less promising results in vitro and in vivo.
Yet, the variability of drug release at the target site remains high, and numerous technical and biological challenges remain to be addressed and overcome. The role of the human microbiome is still not fully understood and premature drug release in the upper gastro intestinal tract is often not sufficiently controlled.
World-wide leading experts in the field from academia and industry will present and discuss with the audience. This includes :
Lille can be easily reached by train (TGV and Eurostar: 30 mn from Brussels, 50 mn from Paris, 1.30 h from London), by plane (Lille Lesquin Airport, or Paris Charles de Gaulle Airport & 50 min by train, or Brussels International Airport & 30 min by train), as well as by car.
For APGI members: 50€ + 20% VAT for lunch and coffee breaks
Non APGI members are asked to become members for the year 2022. Please note that there is no automatic membership renewal for 2023. No action needs to be taken in case you do not want to stay member after 2023. Being a member in 2022 will aslo allow you to benefit from reduced or waived registration fees for the APGI events during this year.
Registration will stard in September through our website.
Please note that number of places is limited to 170 (depending on COVID situation, this number might have to be adjusted).
Several options will be available soon