Hot Topic Day “Local controlled drug delivery”

29th November 2022, Lille, France

See below for registration details

The APGI and the Interreg 2 Seas project “Site Drug: Specifc Drug Delivery” (www.site-drug.org) are jointly organizing a “Hot Topic Day” dedicated to a highly challenging field of research and development: Local Controlled Drug Delivery.

The large majority of drug products available on the market deliver the drug in a non-targeted manner into the human body: The drug is circulated via the blood throughout the entire organism.

Parts of it reach the target site (e.g., a specific organ). However, the large majority of the administered drug dose is distributed within the rest of the body. Importantly, this drug is not only “lost” for the treatment, it is often harmful for the patient, causing potentially severe side effects.

The latter have 3 major consequences, they:

• constitute a major health burden for the patient (e.g. causing nausea, headache, cardiovascular complications)
• can limit the drug dose that can be given to the patient, leading to non-optimal therapeutic effects (the drug amount reaching the target site cannot be further increased)
• cause considerable costs for the health care systems (e.g. due to the treatment of side effects, prolonged).

The aim of the “Site Drug” project is to develop innovative drug products, which are able to control the resulting drug distribution in the patient’s body: The drug amount at th site of action is optimized, and the amount that is “lost” into the rest of the human body is minimized.

The Hot Topic Day will be held in-person to allow for intensive exchanges. The scientific programme is as follows:

9:00-9:10 Welcome

Parenteral Local Controlled Drug Delivery

9:10-9:45

A new understanding of drug release from PLGA-based drug delivery systems

Prof. Juergen Siepmann, University of Lille, France

9:45-10:20

Local periodontitis treatments: Formulation strategies and clinical aspects

Prof. Florence Siepmann and Dr. Kevimy Agossa, University of Lille, France

10:20-10:50 Coffee break

Oral Local Controlled Drug Delivery

10:50-11:25

Colon targeting: Opportunities and pitfalls

Prof. Abdul Basit, University College London, UK

11:25-12:00

Advanced in vitro drug release testing along the gastrointestinal tract

Dr. Frédéric Moens, ProDigest, Belgium

12:00-13:30 Lunch break

Advanced Characterization Methods: In vitro and in vivo

13:30-14:05

Cutting edge characterization techniques for local drug delivery systems

Prof. Axel Zeitler, University of Cambridge, UK

14:05-14:40

Zebra fish: An interesting in vivo model for drug product development

Prof. Jeroen Bussmann, University of Leiden, The Netherlands

14:40-15:10 Coffee break

Manufacturing of Local Drug Delivery Systems

15:10-15:45

The potential of 3D Printing for local controlled drug delivery

Dr. Alvaro Goyanes, FabRx, London, UK

15:45-16:20

An Engineering perspective on 3D printing of local drug delivery systems

Dr. Julian Apachitei, University of Delft, The Netherlands

16:20-16:55

Toward continuous manufacturing of local drug delivery systems

Prof. Chris Vervaet, University of Ghent, Belgium

16:55-17:00 Closing

Registration will open in September